I had the same problem with interruptions in the audio.  Changing buffer settings made it more or less frequent but never eliminated it.  Changing from VB-Cables to my motherboard's Stereo Mix device made it much more manageable.  Changing to Virtual Audio Cable (not VB-Cables) made it almost non-existent.  But the thing that absolutely eliminated it was running a device other than the SDRplay!  So far I've tried an Airspy and an RX-888 and neither have any audio glitches at all.  I have no idea why there's a problem with the SDRplay.  The only thing I can think of that sets it apart is that they have their weird API that uses a server process instead of just a device driver.  But yet the audio works fine with their own SDRuno software.